Thinking Skills Take Biggest Hit from Anxiety in Midlife Women with HIV


HIV News LogoCLEVELAND, Ohio (Friday, February 7, 2014) – Hot flashes, depression, and most of all, anxiety, affect the thinking skills of midlife women with HIV, so screening for and treating their anxiety may be especially important in helping them function, according to a study just published online in Menopause, the journal of The North American Menopause Society (NAMS). The reproductive stage, whether it was premenopause, perimenopause or postmenopause, did not seem to be related to these women’s thinking skills.

The conclusions come from a new analysis of data on 708 HIV-infected and 278 HIV-uninfected midlife women from the Women’s Interagency HIV Study (WHIS), a national study of women with HIV at six sites across the country (Chicago, Bronx, Brooklyn, San Francisco, Los Angeles, and Washington, DC). Today, nearly 52% of persons with HIV/AIDS are 40 to 54 years old. Because more women with HIV are now living to midlife and beyond, it is important to understand what challenges menopause pose for them. We learned just recently, from a study published online in Menopause in July, that women with HIV do face a bigger menopause challenge than uninfected women because they have worse menopause symptoms.

Whether, how, and when the process of transitioning through menopause affects cognition have been debated. Large-scale studies of healthy women indicate that the menopause-related thinking deficiencies are modest, limited to the time leading up to menopause (“perimenopause”), and rebound after
menopause. But in these women who underwent mental skills testing, menopause symptoms and mood symptoms did affect thinking skills.

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